Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells

BACKGROUND: The role of anaplerotic nutrient entry into the Krebs cycle via pyruvate carboxylase has been the subject of increased scrutiny and in particular whether this is dysregulated in cancer. Here, we use a tracer-based NMR analysis involving high-resolution (1)H-(13)C-HSQC spectra to assess s...

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Udgivet i:Cancer Metab
Main Authors: Reed, Michelle A. C., Ludwig, Christian, Bunce, Christopher M., Khanim, Farhat L., Günther, Ulrich L.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972992/
https://ncbi.nlm.nih.gov/pubmed/27493727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-016-0155-7
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