Comparative transcriptomic analysis reveals the oncogenic fusion protein PAX3-FOXO1 globally alters mRNA and miRNA to enhance myoblast invasion

Rhabdomyosarcoma, one of the most common childhood sarcomas, is comprised of two main subtypes, embryonal and alveolar (ARMS). ARMS, the more aggressive subtype, is primarily characterized by the t(2;13)(p35;p14) chromosomal translocation, which fuses two transcription factors, PAX3 and FOXO1 to gen...

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Publicat a:Oncogenesis
Autors principals: Loupe, J M, Miller, P J, Bonner, B P, Maggi, E C, Vijayaraghavan, J, Crabtree, J S, Taylor, C M, Zabaleta, J, Hollenbach, A D
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Short Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972903/
https://ncbi.nlm.nih.gov/pubmed/27454080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2016.53
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