ASCL1 and NEUROD1 reveal heterogeneity in pulmonary neuroendocrine tumors and regulate distinct genetic programs

Small cell lung carcinoma (SCLC) is a high-grade pulmonary neuroendocrine tumor. The transcription factors ASCL1 and NEUROD1 play crucial roles in promoting malignant behavior and survival of human SCLC cell lines. We find ASCL1 and NEUROD1 identify heterogeneity in SCLC, bind distinct genomic loci,...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Borromeo, Mark D., Savage, Trisha K., Kollipara, Rahul K., He, Min, Augustyn, Alexander, Osborne, Jihan K., Girard, Luc, Minna, John D., Gazdar, Adi F., Cobb, Melanie H., Johnson, Jane E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972690/
https://ncbi.nlm.nih.gov/pubmed/27452466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.081
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados