Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.

The A4 or beta protein is a peptide that constitutes the major protein component of senile plaques in Alzheimer disease. The A4/beta protein is derived from a larger, transmembrane amyloid precursor protein (APP). The putative abnormal processing events leading to amyloid accumulation are largely un...

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Bibliographic Details
Main Authors: Knauer, M F, Soreghan, B, Burdick, D, Kosmoski, J, Glabe, C G
Format: Artigo
Language:Inglês
Published: 1992
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC49725/
https://ncbi.nlm.nih.gov/pubmed/1502155
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