Population pharmacokinetic analysis to recommend the optimal dose of udenafil in patients with mild and moderate hepatic impairment

AIMS: The aim of this study was to develop a population pharmacokinetic (PK) model of udenafil and its active metabolite, DA‐8164, in healthy subjects and patients with hepatic impairment (HI) and to estimate the optimal dosing recommendations for patients with HI. METHODS: An open label, three para...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Kim, Anhye, Lee, Jongtae, Shin, Donghoon, Jung, Yong Jin, Bahng, Mi Young, Cho, Joo‐Youn, Jang, In‐Jin
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Pharmacokinetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972155/
https://ncbi.nlm.nih.gov/pubmed/27084997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12977
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