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Viral-mediated Ntf3 overexpression disrupts innervation and hearing in nondeafened guinea pig cochleae

Synaptopathy in the cochlea occurs when the connection between inner hair cells and the auditory nerve is disrupted, leading to impaired hearing and nerve degeneration. Experiments using transgenic mice have shown that overexpression of NT3 by supporting cells repairs synaptopathy caused by overstim...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Lee, Min Young, Kurioka, Takaomi, Nelson, Megan M, Prieskorn, Diane M, Swiderski, Donald L, Takada, Yohei, Beyer, Lisa A, Raphael, Yehoash
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972090/
https://ncbi.nlm.nih.gov/pubmed/27525291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.52
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