Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea

Mature mammalian cochlear hair cells (HCs) do not spontaneously regenerate once lost, leading to life-long hearing deficits. Attempts to induce HC regeneration in adult mammals have used over-expression of the HC-specific transcription factor Atoh1, but to date this approach has yielded low and vari...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lee, Sungsu, Song, Jae-Jun, Beyer, Lisa A., Swiderski, Donald L., Prieskorn, Diane M., Acar, Melih, Jen, Hsin-I, Groves, Andrew K., Raphael, Yehoash
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722738/
https://ncbi.nlm.nih.gov/pubmed/33293609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78167-8
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