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Delivering Transgenic DNA Exceeding the Carrying Capacity of AAV Vectors

Gene delivery using recombinant adeno-associated virus (rAAV) has emerged to the forefront demonstrating safe and effective phenotypic correction of diverse diseases including hemophilia B and Leber’s congenital amaurosis. In addition to rAAV’s high efficiency of transduction and the capacity for lo...

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Detalhes bibliográficos
Publicado no:Methods Mol Biol
Main Authors: Hirsch, Matthew L., Wolf, Sonya J., Samulski, R.J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971574/
https://ncbi.nlm.nih.gov/pubmed/26611576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-3271-9_2
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