Ribosomal DNA Integrating rAAV-rDNA Vectors Allow for Stable Transgene Expression

Although recombinant adeno-associated virus (rAAV) vectors are proving to be efficacious in clinical trials, the episomal character of the delivered transgene restricts their effectiveness to use in quiescent tissues, and may not provide lifelong expression. In contrast, integrating vectors enhance...

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Bibliographic Details
Main Authors: Lisowski, Leszek, Lau, Ashley, Wang, Zhongya, Zhang, Yue, Zhang, Feijie, Grompe, Markus, Kay, Mark A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464642/
https://ncbi.nlm.nih.gov/pubmed/22990671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.164
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