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Ribosomal DNA Integrating rAAV-rDNA Vectors Allow for Stable Transgene Expression
Although recombinant adeno-associated virus (rAAV) vectors are proving to be efficacious in clinical trials, the episomal character of the delivered transgene restricts their effectiveness to use in quiescent tissues, and may not provide lifelong expression. In contrast, integrating vectors enhance...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3464642/ https://ncbi.nlm.nih.gov/pubmed/22990671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.164 |
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