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Temperature-Jump Fluorescence Provides Evidence for Fully Reversible Microsecond Dynamics in a Thermophilic Alcohol Dehydrogenase

[Image: see text] Protein dynamics on the microsecond (μs) time scale were investigated by temperature-jump fluorescence spectroscopy as a function of temperature in two variants of a thermophilic alcohol dehydrogenase: W87F and W87F:H43A. Both mutants exhibit a fast, temperature-independent μs decr...

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Publicat a:J Am Chem Soc
Autors principals: Meadows, Corey W., Balakrishnan, Gurusamy, Kier, Brandon L., Spiro, Thomas G., Klinman, Judith P.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2015
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970856/
https://ncbi.nlm.nih.gov/pubmed/26223665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04413
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