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His26 Protonation in Cytochrome c Triggers Microsecond β-sheet Formation and Heme Exposure: Implications for Apoptosis
Cytochrome c unfolds locally and reversibly upon heating at pH 3. UV resonance Raman (UVRR) spectra reveal that instead of producing unordered structure, unfolding converts turns and some helical elements to β-sheet. It also disrupts the Met80-heme bond, and was earlier shown to induce peroxidase ac...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3529097/ https://ncbi.nlm.nih.gov/pubmed/23094892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja307100a |
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