Effect of food on the pharmacokinetics of TAS‐102 and its efficacy and safety in patients with advanced solid tumors

TAS‐102, a novel oral antitumor agent, consists of trifluridine and tipiracil hydrochloride (molar ratio, 1:0.5). We investigated the effects of food on trifluridine and tipiracil hydrochloride. The efficacy and safety of TAS‐102 were evaluated in patients with advanced solid tumors. We analyzed dru...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Sci
Prif Awduron: Yoshino, Takayuki, Kojima, Takashi, Bando, Hideaki, Yamazaki, Tomoko, Naito, Yoichi, Mukai, Hirofumi, Fuse, Nozomu, Goto, Koichi, Ito, Yuko, Doi, Toshihiko, Ohtsu, Atsushi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970833/
https://ncbi.nlm.nih.gov/pubmed/26918279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12912
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