Effect of food on the pharmacokinetics of TAS‐102 and its efficacy and safety in patients with advanced solid tumors

TAS‐102, a novel oral antitumor agent, consists of trifluridine and tipiracil hydrochloride (molar ratio, 1:0.5). We investigated the effects of food on trifluridine and tipiracil hydrochloride. The efficacy and safety of TAS‐102 were evaluated in patients with advanced solid tumors. We analyzed dru...

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Detalles Bibliográficos
Publicado en:Cancer Sci
Main Authors: Yoshino, Takayuki, Kojima, Takashi, Bando, Hideaki, Yamazaki, Tomoko, Naito, Yoichi, Mukai, Hirofumi, Fuse, Nozomu, Goto, Koichi, Ito, Yuko, Doi, Toshihiko, Ohtsu, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970833/
https://ncbi.nlm.nih.gov/pubmed/26918279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12912
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