Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans

The bioactive sphingolipid sphingosine-1-phosphate (S1P) and the kinase that produces it have been implicated in inflammatory bowel diseases in mice and humans; however, little is known about the role of the 2 S1P-specific phosphohydrolase isoforms, SGPP1 and SGPP2, which catalyze dephosphorylation...

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Bibliographic Details
Published in:FASEB J
Main Authors: Huang, Wei-Ching, Liang, Jie, Nagahashi, Masayuki, Avni, Dorit, Yamada, Akimitsu, Maceyka, Michael, Wolen, Aaron R., Kordula, Tomasz, Milstien, Sheldon, Takabe, Kazuaki, Oravecz, Tamas, Spiegel, Sarah
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2016
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970610/
https://ncbi.nlm.nih.gov/pubmed/27130484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600394R
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