Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

Inflammatory bowel disease is an important risk factor for colorectal cancer. We show that sphingosine-1-phosphate (S1P) produced by upregulation of sphingosine kinase 1 (SphK1) links chronic intestinal inflammation to colitis-associated cancer (CAC) and both are exacerbated by deletion of Sphk2. S1...

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Hauptverfasser: Liang, Jie, Nagahashi, Masayuki, Kim, Eugene Y., Harikumar, Kuzhuvelil B., Yamada, Akimitsu, Huang, Wei-Ching, Hait, Nitai C., Allegood, Jeremy C., Price, Megan M., Avni, Dorit, Takabe, Kazuaki, Kordula, Tomasz, Milstien, Sheldon, Spiegel, Sarah
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578577/
https://ncbi.nlm.nih.gov/pubmed/23273921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.11.013
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