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Targeting Sphingosine-1-Phosphate in Hematologic Malignancies

Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid mediator that regulates several processes important for hematologic cancer progression. S1P is generated by two sphingosine kinases, SphK1 and SphK2, and is exported outside the cell, where it activates specific cell surface S1P G-protei...

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Detalhes bibliográficos
Main Authors: Stevenson, Christina E., Takabe, Kazuaki, Nagahashi, Masayuki, Milstien, Sheldon, Spiegel, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368248/
https://ncbi.nlm.nih.gov/pubmed/21707492
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