Kidney epithelium specific deletion of kelch-like ECH-associated protein 1 (Keap1) causes hydronephrosis in mice

BACKGROUND: Transcription factor Nrf2 protects from experimental acute kidney injury (AKI) and is promising to limit progression in human chronic kidney disease (CKD) by upregulating multiple antioxidant genes. We recently demonstrated that deletion of Keap1, the endogenous inhibitor of Nrf2, in T l...

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Vydáno v:BMC Nephrol
Hlavní autoři: Noel, Sanjeev, Arend, Lois J., Bandapalle, Samatha, Reddy, Sekhar P., Rabb, Hamid
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969727/
https://ncbi.nlm.nih.gov/pubmed/27484495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12882-016-0310-y
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