A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition

Autophagy dysfunction is a common feature in neurodegenerative disorders characterized by accumulation of toxic protein aggregates. Increasing evidence has demonstrated that activation of TFEB (transcription factor EB), a master regulator of autophagy and lysosomal biogenesis, can ameliorate neuroto...

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Pubblicato in:Autophagy
Autori principali: Song, Ju-Xian, Sun, Yue-Ru, Peluso, Ivana, Zeng, Yu, Yu, Xing, Lu, Jia-Hong, Xu, Zheng, Wang, Ming-Zhong, Liu, Liang-Feng, Huang, Ying-Yu, Chen, Lei-Lei, Durairajan, Siva Sundara Kumar, Zhang, Hong-Jie, Zhou, Bo, Zhang, Hong-Qi, Lu, Aiping, Ballabio, Andrea, Medina, Diego L., Guo, Zhihong, Li, Min
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
Soggetti:
Translational Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968239/
https://ncbi.nlm.nih.gov/pubmed/27172265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1179404
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