SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages

Proper regulation of mitophagy for mitochondrial homeostasis is important in various inflammatory diseases. However, the precise mechanisms by which mitophagy is activated to regulate inflammatory responses remain largely unknown. The NLRP3 (NLR family, pyrin domain containing 3) inflammasome serves...

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Gepubliceerd in:Autophagy
Hoofdauteurs: Kim, Min-Ji, Bae, Soo Han, Ryu, Jae-Chan, Kwon, Younghee, Oh, Ji-Hwan, Kwon, Jeongho, Moon, Jong-Seok, Kim, Kyubo, Miyawaki, Atsushi, Lee, Min Goo, Shin, Jaekyoon, Kim, Young Sam, Kim, Chang-Hoon, Ryter, Stefan W., Choi, Augustine M. K., Rhee, Sue Goo, Ryu, Ji-Hwan, Yoon, Joo-Heon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2016
Onderwerpen:
Basic Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968237/
https://ncbi.nlm.nih.gov/pubmed/27337507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1183081
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