SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages

Proper regulation of mitophagy for mitochondrial homeostasis is important in various inflammatory diseases. However, the precise mechanisms by which mitophagy is activated to regulate inflammatory responses remain largely unknown. The NLRP3 (NLR family, pyrin domain containing 3) inflammasome serves...

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Publicado en:Autophagy
Autores principales: Kim, Min-Ji, Bae, Soo Han, Ryu, Jae-Chan, Kwon, Younghee, Oh, Ji-Hwan, Kwon, Jeongho, Moon, Jong-Seok, Kim, Kyubo, Miyawaki, Atsushi, Lee, Min Goo, Shin, Jaekyoon, Kim, Young Sam, Kim, Chang-Hoon, Ryter, Stefan W., Choi, Augustine M. K., Rhee, Sue Goo, Ryu, Ji-Hwan, Yoon, Joo-Heon
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
Materias:
Basic Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968237/
https://ncbi.nlm.nih.gov/pubmed/27337507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1183081
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