Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering

Undesired solution behaviors such as reversible self-association (RSA), high viscosity, and liquid-liquid phase separation can introduce substantial challenges during development of monoclonal antibody formulations. Although a global mechanistic understanding of RSA (i.e., native and reversible prot...

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Publicado en:MAbs
Main Authors: Geoghegan, James C., Fleming, Ryan, Damschroder, Melissa, Bishop, Steven M., Sathish, Hasige A., Esfandiary, Reza
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968137/
https://ncbi.nlm.nih.gov/pubmed/27050875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1171444
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