Enhanced rational protein engineering to reduce viscosity in high-concentration IgG1 antibody solutions

Subcutaneous (SC) delivery of therapeutic antibodies can offer multiple benefits to patients and healthcare providers, including convenience, time savings, and cost reduction. To improve the SC injection experience, drug developers may seek a low injection volume (1–2 mL), which for some antibody dr...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Tyler J. Lefevre, Jenna G. Caldwell, Austin Gallegos, Qun Du, Erin Houston, Gilad Kaplan, Reza Esfandiary
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Taylor & Francis Group 2025-12-01
סדרה:	mAbs
נושאים:	Antibody developability HDX-MS high concentration in silico mab
גישה מקוונת:	https://www.tandfonline.com/doi/10.1080/19420862.2025.2543771
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