Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity

Preferential interactions of excipients with the antibody surface govern their effect on the stability of antibodies in solution. We probed the preferential interactions of proline, arginine.HCl (Arg.HCl), and NaCl with three therapeutically relevant IgG1 antibodies via experiment and simulation. Wi...

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Publicado en:MAbs
Main Authors: Cloutier, Theresa K., Sudrik, Chaitanya, Mody, Neil, Hasige, Sathish A., Trout, Bernhardt L.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531574/
https://ncbi.nlm.nih.gov/pubmed/32938318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1816312
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