Characterization of alanine to valine sequence variants in the Fc region of nivolumab biosimilar produced in Chinese hamster ovary cells

Nivolumab is a therapeutic fully human IgG4 antibody to programmed death 1 (PD-1). In this study, a nivolumab biosimilar, which was produced in our laboratory, was analyzed and characterized. Sequence variants that contain undesired amino acid sequences may cause concern during biosimilar bioprocess...

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Publicat a:MAbs
Autors principals: Li, Yantao, Fu, Tuo, Liu, Tao, Guo, Huaizu, Guo, Qingcheng, Xu, Jin, Zhang, Dapeng, Qian, Weizhu, Dai, Jianxin, Li, Bohua, Guo, Yajun, Hou, Sheng, Wang, Hao
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
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Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968099/
https://ncbi.nlm.nih.gov/pubmed/27050807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1172150
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