Acid-induced aggregation propensity of nivolumab is dependent on the Fc

Nivolumab, an anti-programmed death (PD)1 IgG(4) antibody, has shown notable success as a cancer treatment. Here, we report that nivolumab was susceptible to aggregation during manufacturing, particularly in routine purification steps. Our experimental results showed that exposure to low pH caused a...

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Pubblicato in:MAbs
Autori principali: Liu, Boning, Guo, Huaizu, Xu, Jin, Qin, Ting, Xu, Lu, Zhang, Junjie, Guo, Qingcheng, Zhang, Dapeng, Qian, Weizhu, Li, Bohua, Dai, Jianxin, Hou, Sheng, Guo, Yajun, Wang, Hao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968106/
https://ncbi.nlm.nih.gov/pubmed/27310175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1197443
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