Llwytho...

Evaluation of novel synthetic TLR7/8 agonists as vaccine adjuvants

Small-molecule adjuvants that boost and direct adaptive immunity provide a powerful means to increase the effectiveness of vaccines. Through rational design several novel imidazoquinoline and oxoadenine TLR7/8 agonists, each with unique molecular modifications, were synthesized and assessed for thei...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Vaccine
Prif Awduron: Smith, Alyson J., Li, Yufeng, Bazin, Hélène G., St-Jean, Julien R., Larocque, Daniel, Evans, Jay T., Baldridge, Jory R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968040/
https://ncbi.nlm.nih.gov/pubmed/27402566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2016.06.080
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