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Evaluation of novel synthetic TLR7/8 agonists as vaccine adjuvants
Small-molecule adjuvants that boost and direct adaptive immunity provide a powerful means to increase the effectiveness of vaccines. Through rational design several novel imidazoquinoline and oxoadenine TLR7/8 agonists, each with unique molecular modifications, were synthesized and assessed for thei...
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| Опубликовано в: : | Vaccine |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4968040/ https://ncbi.nlm.nih.gov/pubmed/27402566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2016.06.080 |
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