Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication

Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental stress. This disruption mechanism was largely expla...

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Bibliografiska uppgifter
I publikationen:Open Biol
Huvudupphovsmän: Schulte, Tim, Liu, Lifeng, Panas, Marc D., Thaa, Bastian, Dickson, Nicole, Götte, Benjamin, Achour, Adnane, McInerney, Gerald M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Royal Society 2016
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967826/
https://ncbi.nlm.nih.gov/pubmed/27383630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160078
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