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Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication

Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental stress. This disruption mechanism was largely expla...

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Detalhes bibliográficos
Publicado no:Open Biol
Main Authors: Schulte, Tim, Liu, Lifeng, Panas, Marc D., Thaa, Bastian, Dickson, Nicole, Götte, Benjamin, Achour, Adnane, McInerney, Gerald M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967826/
https://ncbi.nlm.nih.gov/pubmed/27383630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160078
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