Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding and transcription

The NF-κB signalling module controls transcription through a network of protein kinases such as the IKKs, as well as inhibitory proteins (IκBs) and transcription factors including RelA/p65. Phosphorylation of the NF-κB subunits is critical for dictating system dynamics. Using both non-targeted disco...

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Detalhes bibliográficos
Publicado no:Open Biol
Main Authors: Lanucara, Francesco, Lam, Connie, Mann, Jelena, Monie, Tom P., Colombo, Stefano A. P., Holman, Stephen W., Boyd, James, Dange, Manohar C., Mann, Derek A., White, Michael R. H., Eyers, Claire E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967822/
https://ncbi.nlm.nih.gov/pubmed/27466442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160055
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