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Exploring the biophysical evidence that mammalian two‐pore channels are NAADP‐activated calcium‐permeable channels

Nicotinic acid adenine dinucleotide phosphate (NAADP) potently releases Ca(2+) from acidic intracellular endolysosomal Ca(2+) stores. It is widely accepted that two types of two‐pore channels, termed TPC1 and TPC2, are responsible for the NAADP‐mediated Ca(2+) release but the underlying mechanisms r...

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Pubblicato in:J Physiol
Autori principali: Pitt, Samantha J., Reilly‐O'Donnell, Benedict, Sitsapesan, Rebecca
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967738/
https://ncbi.nlm.nih.gov/pubmed/26872338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP270936
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