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Sarcomere neutralization in inherited cardiomyopathy: small-molecule proof-of-concept to correct hyper-Ca(2+)-sensitive myofilaments
The sarcomere is the functional unit of the heart. Alterations in sarcomere activation lead to disease states such as hypertrophic and restrictive cardiomyopathy (HCM/RCM). Mutations in many of the sarcomeric genes are causal for HCM/RCM. In most cases, these mutations result in increased Ca(2+) sen...
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| 出版年: | Am J Physiol Heart Circ Physiol |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Physiological Society
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4967205/ https://ncbi.nlm.nih.gov/pubmed/27199134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00981.2015 |
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