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Sarcomere neutralization in inherited cardiomyopathy: small-molecule proof-of-concept to correct hyper-Ca(2+)-sensitive myofilaments

The sarcomere is the functional unit of the heart. Alterations in sarcomere activation lead to disease states such as hypertrophic and restrictive cardiomyopathy (HCM/RCM). Mutations in many of the sarcomeric genes are causal for HCM/RCM. In most cases, these mutations result in increased Ca(2+) sen...

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書誌詳細
出版年:Am J Physiol Heart Circ Physiol
主要な著者: Thompson, Brian R., Martindale, Joshua, Metzger, Joseph M.
フォーマット: Artigo
言語:Inglês
出版事項: American Physiological Society 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967205/
https://ncbi.nlm.nih.gov/pubmed/27199134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00981.2015
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