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Arrhythmogenic Current Generation by Myofilament-Triggered Ca(2+) Release and Sarcomere Heterogeneity

Heterogeneous mechanical dyskinesis has been implicated in many arrhythmogenic phenotypes. Strain-dependent perturbations to cardiomyocyte electrophysiology may contribute to this arrhythmogenesis through processes referred to as mechanoelectric feedback. Although the role of stretch-activated ion c...

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Pubblicato in:Biophys J
Autori principali: Timmermann, Viviane, Edwards, Andrew G., Wall, Samuel T., Sundnes, Joakim, McCulloch, Andrew D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6990379/
https://ncbi.nlm.nih.gov/pubmed/31810659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.11.009
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