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Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension

Epigenetic mechanisms, including DNA methylation and histone acetylation, regulate gene expression in idiopathic pulmonary arterial hypertension (IPAH). These mechanisms can modulate expression of extracellular superoxide dismutase (SOD3 or EC-SOD), a key vascular antioxidant enzyme, and loss of vas...

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Bibliografski detalji
Izdano u:Am J Physiol Lung Cell Mol Physiol
Glavni autori: Nozik-Grayck, Eva, Woods, Crystal, Stearman, Robert S., Venkataraman, Sujatha, Ferguson, Bradley S., Swain, Kalin, Bowler, Russell P., Geraci, Mark W., Ihida-Stansbury, Kaori, Stenmark, Kurt R., McKinsey, Timothy A., Domann, Frederick E.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967185/
https://ncbi.nlm.nih.gov/pubmed/27233998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00263.2015
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