Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension

Epigenetic mechanisms, including DNA methylation and histone acetylation, regulate gene expression in idiopathic pulmonary arterial hypertension (IPAH). These mechanisms can modulate expression of extracellular superoxide dismutase (SOD3 or EC-SOD), a key vascular antioxidant enzyme, and loss of vas...

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Pubblicato in:Am J Physiol Lung Cell Mol Physiol
Autori principali: Nozik-Grayck, Eva, Woods, Crystal, Stearman, Robert S., Venkataraman, Sujatha, Ferguson, Bradley S., Swain, Kalin, Bowler, Russell P., Geraci, Mark W., Ihida-Stansbury, Kaori, Stenmark, Kurt R., McKinsey, Timothy A., Domann, Frederick E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2016
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967185/
https://ncbi.nlm.nih.gov/pubmed/27233998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00263.2015
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