Superoxide Dismutase 3 R213G Single-Nucleotide Polymorphism Blocks Murine Bleomycin-Induced Fibrosis and Promotes Resolution of Inflammation

Loss of extracellular superoxide dismutase 3 (SOD3) contributes to inflammatory and fibrotic lung diseases. The human SOD3 R213G polymorphism decreases matrix binding, redistributing SOD3 from the lung to extracellular fluids, and protects against LPS-induced alveolar inflammation. We used R213G mic...

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Библиографические подробности
Опубликовано в: :Am J Respir Cell Mol Biol
Главные авторы: Mouradian, Gary C., Gaurav, Rohit, Pugliese, Steve, El Kasmi, Karim, Hartman, Brittany, Hernandez-Lagunas, Laura, Stenmark, Kurt R., Bowler, Russell P., Nozik-Grayck, Eva
Формат: Artigo
Язык:Inglês
Опубликовано: American Thoracic Society 2017
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359538/
https://ncbi.nlm.nih.gov/pubmed/27805412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0153OC
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