Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody

X-ray structure analysis of 4 antibody Fab fragments, each in complex with human granulocyte macrophage colony stimulating factor (GM-CSF), was performed to investigate the changes at the protein-protein binding interface during the course of in vitro affinity maturation by phage display selection....

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Veröffentlicht in:MAbs
Hauptverfasser: Eylenstein, Roy, Weinfurtner, Daniel, Härtle, Stefan, Strohner, Ralf, Böttcher, Jark, Augustin, Martin, Ostendorp, Ralf, Steidl, Stefan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966552/
https://ncbi.nlm.nih.gov/pubmed/26406987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1099774
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