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Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody
X-ray structure analysis of 4 antibody Fab fragments, each in complex with human granulocyte macrophage colony stimulating factor (GM-CSF), was performed to investigate the changes at the protein-protein binding interface during the course of in vitro affinity maturation by phage display selection....
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| Publicado no: | MAbs |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4966552/ https://ncbi.nlm.nih.gov/pubmed/26406987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1099774 |
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