Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape

In preclinical models of glioblastoma, antigen escape variants can lead to tumor recurrence after treatment with CAR T cells that are redirected to single tumor antigens. Given the heterogeneous expression of antigens on glioblastomas, we hypothesized that a bispecific CAR molecule would mitigate an...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Hegde, Meenakshi, Mukherjee, Malini, Grada, Zakaria, Pignata, Antonella, Landi, Daniel, Navai, Shoba A., Wakefield, Amanda, Fousek, Kristen, Bielamowicz, Kevin, Chow, Kevin K.H., Brawley, Vita S., Byrd, Tiara T., Krebs, Simone, Gottschalk, Stephen, Wels, Winfried S., Baker, Matthew L., Dotti, Gianpietro, Mamonkin, Maksim, Brenner, Malcolm K., Orange, Jordan S., Ahmed, Nabil
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2016
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966331/
https://ncbi.nlm.nih.gov/pubmed/27427982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83416
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items