Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape

In preclinical models of glioblastoma, antigen escape variants can lead to tumor recurrence after treatment with CAR T cells that are redirected to single tumor antigens. Given the heterogeneous expression of antigens on glioblastomas, we hypothesized that a bispecific CAR molecule would mitigate an...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Hegde, Meenakshi, Mukherjee, Malini, Grada, Zakaria, Pignata, Antonella, Landi, Daniel, Navai, Shoba A., Wakefield, Amanda, Fousek, Kristen, Bielamowicz, Kevin, Chow, Kevin K.H., Brawley, Vita S., Byrd, Tiara T., Krebs, Simone, Gottschalk, Stephen, Wels, Winfried S., Baker, Matthew L., Dotti, Gianpietro, Mamonkin, Maksim, Brenner, Malcolm K., Orange, Jordan S., Ahmed, Nabil
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966331/
https://ncbi.nlm.nih.gov/pubmed/27427982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83416
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados