Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape

In preclinical models of glioblastoma, antigen escape variants can lead to tumor recurrence after treatment with CAR T cells that are redirected to single tumor antigens. Given the heterogeneous expression of antigens on glioblastomas, we hypothesized that a bispecific CAR molecule would mitigate an...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Hegde, Meenakshi, Mukherjee, Malini, Grada, Zakaria, Pignata, Antonella, Landi, Daniel, Navai, Shoba A., Wakefield, Amanda, Fousek, Kristen, Bielamowicz, Kevin, Chow, Kevin K.H., Brawley, Vita S., Byrd, Tiara T., Krebs, Simone, Gottschalk, Stephen, Wels, Winfried S., Baker, Matthew L., Dotti, Gianpietro, Mamonkin, Maksim, Brenner, Malcolm K., Orange, Jordan S., Ahmed, Nabil
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966331/
https://ncbi.nlm.nih.gov/pubmed/27427982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83416
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