Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia

Previous studies revealed a paradox whereby mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) acted as a negative regulator of insulin sensitivity in chronically obese mice, yet systemic deletion of Map4k4 did not improve glucose tolerance. Here, we report markedly reduced glucose-res...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Roth Flach, Rachel J., Danai, Laura V., DiStefano, Marina T., Kelly, Mark, Menendez, Lorena Garcia, Jurczyk, Agata, Sharma, Rohit B., Jung, Dae Young, Kim, Jong Hun, Kim, Jason K., Bortell, Rita, Alonso, Laura C., Czech, Michael P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2016
Gaiak:
Molecular Bases of Disease
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965570/
https://ncbi.nlm.nih.gov/pubmed/27226575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.718932
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