Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia

Previous studies revealed a paradox whereby mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) acted as a negative regulator of insulin sensitivity in chronically obese mice, yet systemic deletion of Map4k4 did not improve glucose tolerance. Here, we report markedly reduced glucose-res...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Roth Flach, Rachel J., Danai, Laura V., DiStefano, Marina T., Kelly, Mark, Menendez, Lorena Garcia, Jurczyk, Agata, Sharma, Rohit B., Jung, Dae Young, Kim, Jong Hun, Kim, Jason K., Bortell, Rita, Alonso, Laura C., Czech, Michael P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2016
Aiheet:
Molecular Bases of Disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965570/
https://ncbi.nlm.nih.gov/pubmed/27226575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.718932
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