Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy

Phosphatase and tensin homolog-induced putative kinase 1 (PINK1), a Ser/Thr kinase, and PARKIN, a ubiquitin ligase, are causal genes for autosomal recessive early-onset parkinsonism. Multiple lines of evidence indicate that PINK1 and PARKIN cooperatively control the quality of the mitochondrial popu...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Akabane, Shiori, Matsuzaki, Kohei, Yamashita, Shun-ichi, Arai, Kana, Okatsu, Kei, Kanki, Tomotake, Matsuda, Noriyuki, Oka, Toshihiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965565/
https://ncbi.nlm.nih.gov/pubmed/27302064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.714923
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