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Dimension of Model Parameter Space and Operating Characteristics in Adaptive Dose-Finding Studies

Adaptive, model-based, dose-finding methods, such as the continual reassessment method, have been shown to have good operating characteristics. One school of thought argues in favour of the use of parsimonious models, not modelling all aspects of the problem, and using a strict minimum number of par...

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Detalhes bibliográficos
Publicado no:Stat Med
Main Authors: Iasonos, Alexia, Wages, Nolan A., Conaway, Mark R., Cheung, Ken, Yuan, Ying, O'Quigley, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965325/
https://ncbi.nlm.nih.gov/pubmed/27090197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6966
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