CD4(+) T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

Mycobacterium tuberculosis (Mtb), possesses at least three type VII secretion systems, ESX-1, -3 and -5 that are actively involved in pathogenesis and host-pathogen interaction. We recently showed that an attenuated Mtb vaccine candidate (Mtb Δppe25-pe19), which lacks the characteristic ESX-5-associ...

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Pubblicato in:PLoS Pathog
Autori principali: Sayes, Fadel, Pawlik, Alexandre, Frigui, Wafa, Gröschel, Matthias I., Crommelynck, Samuel, Fayolle, Catherine, Cia, Felipe, Bancroft, Gregory J., Bottai, Daria, Leclerc, Claude, Brosch, Roland, Majlessi, Laleh
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965174/
https://ncbi.nlm.nih.gov/pubmed/27467705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005770
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