RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

Tuberculosis is the deadliest infectious disease worldwide. Although the BCG vaccine is widely used, it does not efficiently protect against pulmonary tuberculosis and an improved tuberculosis vaccine is therefore urgently needed. Mycobacterium tuberculosis uses different ESX/Type VII secretion (T7S...

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Udgivet i:PLoS Pathog
Main Authors: Ates, Louis S., Sayes, Fadel, Frigui, Wafa, Ummels, Roy, Damen, Merel P. M., Bottai, Daria, Behr, Marcel A., van Heijst, Jeroen W. J., Bitter, Wilbert, Majlessi, Laleh, Brosch, Roland
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023246/
https://ncbi.nlm.nih.gov/pubmed/29912964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007139
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