RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

Tuberculosis is the deadliest infectious disease worldwide. Although the BCG vaccine is widely used, it does not efficiently protect against pulmonary tuberculosis and an improved tuberculosis vaccine is therefore urgently needed. Mycobacterium tuberculosis uses different ESX/Type VII secretion (T7S...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:PLoS Pathog
Κύριοι συγγραφείς: Ates, Louis S., Sayes, Fadel, Frigui, Wafa, Ummels, Roy, Damen, Merel P. M., Bottai, Daria, Behr, Marcel A., van Heijst, Jeroen W. J., Bitter, Wilbert, Majlessi, Laleh, Brosch, Roland
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2018
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023246/
https://ncbi.nlm.nih.gov/pubmed/29912964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007139
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