RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

Tuberculosis is the deadliest infectious disease worldwide. Although the BCG vaccine is widely used, it does not efficiently protect against pulmonary tuberculosis and an improved tuberculosis vaccine is therefore urgently needed. Mycobacterium tuberculosis uses different ESX/Type VII secretion (T7S...

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Publicado en:PLoS Pathog
Main Authors: Ates, Louis S., Sayes, Fadel, Frigui, Wafa, Ummels, Roy, Damen, Merel P. M., Bottai, Daria, Behr, Marcel A., van Heijst, Jeroen W. J., Bitter, Wilbert, Majlessi, Laleh, Brosch, Roland
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023246/
https://ncbi.nlm.nih.gov/pubmed/29912964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007139
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