The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia

The development of alpha7 nicotinic acetylcholine receptor agonists is considered a promising approach for the treatment of cognitive symptoms in schizophrenia patients. In the present studies we characterized the novel agent, (2R)-N-(6-(1H-imidazol-1-yl)-4-pyrimidinyl)-4'H-spiro[4-azabicyclo[2...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bristow, Linda J., Easton, Amy E., Li, Yu-Wen, Sivarao, Digavalli V., Lidge, Regina, Jones, Kelli M., Post-Munson, Debra, Daly, Christopher, Lodge, Nicholas J., Gallagher, Lizbeth, Molski, Thaddeus, Pieschl, Richard, Chen, Ping, Hendricson, Adam, Westphal, Ryan, Cook, James, Iwuagwu, Christiana, Morgan, Daniel, Benitex, Yulia, King, Dalton, Macor, John E., Zaczek, Robert, Olson, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965148/
https://ncbi.nlm.nih.gov/pubmed/27467081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159996
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