Development of 4-Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes] as α7 Nicotinic Receptor Agonists

[Image: see text] We describe the synthesis of quinuclidine-containing spiroimidates and their utility as α7 nicotinic acetylcholine receptor (nAChR) partial agonists. A convergent synthetic route allowed for rapid SAR investigation and provided a diverse set of fused 6,5-heteroaryl analogs. Two pot...

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Hill, Matthew D., Fang, Haiquan, King, H. Dalton, Iwuagwu, Christiana I., McDonald, Ivar M., Cook, James, Zusi, F. Christopher, Mate, Robert A., Knox, Ronald J., Post-Munson, Debra, Easton, Amy, Miller, Regina, Lentz, Kimberley, Clarke, Wendy, Benitex, Yulia, Lodge, Nicholas, Zaczek, Robert, Denton, Rex, Morgan, Daniel, Bristow, Linda, Macor, John E., Olson, Richard
Format: Artigo
Language:Inglês
Published: American Chemical Society 2016
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238485/
https://ncbi.nlm.nih.gov/pubmed/28105289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00471
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